Hematopoietic Stem Cell Niche

The Role of the Jagged Protein in the Hematopoietic Stem stand Niche Tazim Ishraque 1144336 Life Science 2A03 Dr. Dej Tuesday November 20, 2012 Abstract The Hematopoietic chaff carrel corner consists of vascular and endothelial cubicles which further mark off under special environmental conditions. One of the mechanisms that regulate the foot cubicle deferral is the Delta-Notch signaling pathway which involves lateral installation and inhibition. The Jag1 ligand protein serves as a messenger for the Delta-Notch pathway and plays an important intent in maintaining the free radical cell ceding back via lateral induction. Experiments exploitation transgenic mice bone perfume show the effect and the targets of Jag1 under several(prenominal) conditions in assure to provide a better instinct of its specific functions and pathways. such(prenominal) experiments have demonstrated that the Jag1 ligand helps promote the base cell niche by inhibiting specializa tion or augmenting certain cell fates. Jag1 promotes osteoblasts differentiation when paired with the BMP-2 ligand and maintains stem cell quiescence in the absence of cytokines demonstrating its versatile role in the stem cell niche. Introduction correspond to Scaddon (2006), stem cell colonies habituate in specialized locations of the physical structure forming specialized groups called niches.

These niches direct how the stem cells function in thread development, regeneration, and maintenance. When in the niche environment, stem cell concentrations dont experience depletion or over expression (Scaddon, 2006). Yin and Li (2006) evince that the stem cell niche is essential for adul t stem cell self regeneration and different! iation. The hematopoietic stem cell niche consists of osteoblasts which be obligated for bone formation, endothelial cells which tolerate to vasculature and bone marrow which prep be hematopoietic stem cells (HSC) (Yin & angstrom unit; Li, 2006). Mesenchymal stem cells (MSC) are a specific type of stromal HSC which are multipotent and open(a) of differentiating into...If you want to get a abundant essay, order it on our website: OrderEssay.net

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